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Fukuzawa, M., Araki, T., Adrian, I., Williams, G., (2001) ' Tyrosine phosphorylation-independent nuclear translocation of a dictyostelium STAT in response to DIF signaling. ' Mol Cell 7 779-88

 

Abstract:We describe a Dictyostelium STAT, Dd-STATc, which regulates the speed of early development and the timing of terminal differentiation. Dd-STATc also functions as a repressor, which directs graded expression of the ecmA gene in different prestalk cell populations. Developing Dictyostelium cells produce a chlorinated hexaphenone, DIF, which directs prestalk cell differentiation. Dd-STATc is tyrosine phosphorylated, dimerizes, and translocates to the nucleus when cells are exposed to DIF. Surprisingly, however, SH2 domain-phosphotyrosine interaction is not necessary for the DIF-induced nuclear translocation of Dd-STATc. In this respect, Dd-STATc activation resembles several recently described, noncanonical mammalian STAT signaling processes. We show instead that DIF mediates nuclear translocation via sequences located in the divergent, N-terminal half of the Dd-STATc molecule.
Status:	Published	Type:	Journal article	Source:	PUBMED	PubMed ID:	11336701

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	Genes addressed in this paper
	dstA	dstC
Topics in this paper
Protein Functional Domain		X
Cellular Location		X
Post-Translational Modifications		X
Synonym		X
Signal Transduction		X
Development/Morphogenesis		X
Function/Process	X	X
Cell Type Localization		X
Regulatory Role		X
DNA/RNA Sequence Features		X
Regulated By		X
Growth		X
Mutants/Phenotypes		X
Antibodies		X